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The growing burden of chronic metabolic disorders worldwide, combined with increasing healthcare expenditures and stronger clinical emphasis on long-term weight management and glycemic control, is compelling healthcare providers, payers, and patients to adopt advanced GLP-1 agonist therapies

Elevated extracellular lactate, a defining feature of the tumor microenvironment, predicts poor outcomes, and high GPR81 expression correlates with poorer survival (8,53,54)

The other are medications such as Mounjaro and Zepbound that contain the active ingredient tirzepatide

Unlike the allosteric activator compound 102 , the GPX4 inhibitor RSL3 binds to the substrate binding site

GLP-1 receptor agonist effects on lipid and liver profiles in patients with nonalcoholic fatty liver disease: Systematic review and meta-analysis

Endoplasmic reticulum stress in systemic lupus erythematosus and lupus nephritis: potential therapeutic target