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doi: 10.1038/nature07823
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On paper that sounds like a contradiction, and at high doses it would be
39,40 Elevated phosphoribosyl pyrophosphate (PRPP) synthetase activity and deficiency in hypoxanthine phosphoribosyl transferase (HPRT) not only enhance endogenous purine synthesis but also result in excessive production and buildup of uric acid
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