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Malinow's concern was based on the result of our study of the Framingham Offspring cohort (38), which showed that, in subjects who were taking vitamin supplements, folic acid fortification was associated with significantly higher serum total homocysteine (tHcy) concentrations than at baseline ( Figure 2 )
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NAD+ NAD+ (Nicotinamide Adenine Dinucleotide): Essential coenzyme for cellular energy, DNA repair, and anti-aging research
