Just the research
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Recommendations for future research Future research studies should prioritise adequately powered, multicentre, double-blind RCTs of NAC in PD with rigorous controls, standardised dosing regimens, clearly defined routes of administration, and stratification by disease stage and baseline oxidative stress markers to identify patient subgroups most likely to benefit
Abstract With age the apolipoprotein E ( APOE ) E4 allele (involved in lipid homeostasis) is associated with perturbation of bioenergetics pathways in Alzheimers disease (AD)
Nagamine J, Nagata R, Seki H, Nomura-Akimaru N, Ueki Y, Kumagai K, et al
Furthermore, in a mouse model of amyloid pathology, AAV-mediated human ApoE gene expression revealed that the presence of the ApoE4 allele exacerbated synaptic loss and A deposition, while the ApoE2 allele expression in the same model led to a reduction in brain A levels (Yamazaki et al., 2019