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Oxid Med Cell Longev 2022;2022, 1225578
This rebound occurs because the medication addresses appetite regulation, not underlying metabolic programming
Collectively, these metabolites form an integrated, synergistic network that enhances receptor expression, increases ligand availability, and converges on common neuroendocrine circuits, including vagal afferents and hypothalamic pathways, thereby exerting a coordinated regulatory effect on the gutbrain axis (126)
Normal blood levels range from 3.5-5.0 mEq/L
A retrospective cohort study of 78 cases found late remission rates of 64.9% in patients with Knosp 0/2, compared to 47.1% and 25% in patients with Knosp 3 and 4, respectively (54)
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