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E2 binds with high affinity to the large extracellular loop of CD81, a tetraspanin that is expressed on a variety of cell types, including hepatocytes 85

This substance was dissolved in isopropanol/THF (1 L, 1 : 1 v/v), and washed with water (500 mL)

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In PIONEER 2, oral semaglutide reduced CRP by 30%, whereas empagliflozin had no effect despite similar approximately 4% weight loss (24)

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