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Hypomelanotic melanoma is also often difficult to diagnose, as exemplified in a patient with an extensive chronic foot ulcer, in whom attentive dermatoscopic observation revealed that the only atypical pigmented area was at the periphery (Fig

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PMID 19617523

Notably, it can potentially affect the efficacy or side-effect profile of drugs such as nitroglycerin, nitrates, and some chemotherapy agents