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This deficiency can exacerbate oxidative stress and impair detoxification pathways, potentially contributing to the symptoms and comorbidities associated with autism

This study provides an early report of the loss of glial cells within the PFC of patients with mood disorders, consistent with the hypothesized glutamate abnormalities in these disorders

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These include immune-mediated cytokine release, hormonal modulation through the hypothalamicpituitaryadrenal (HPA) axis, and neural pathways involving both the enteric nervous system (ENS) and the vagus nerve (Guzzetta et al., 2022

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