Many bacteria carry a plasmid-encoded glutathione S-transferase (FosA) that conjugates GSH to fosfomycin, opening the epoxide ring and inactivating the drug
Scientific Insights: NSAIDs and Glutathione Depletion While NSAIDs are effective for managing pain and inflammation, studies suggest that they may contribute to glutathione depletion, particularly in the liver, where detoxification processes are heavily reliant on this antioxidant
J Endocrinol
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N-acetylcysteine is a precursor to glutathione
Sinha R, Sinha I, Calcagnotto A, et al