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- Discontinue use if irritation occurs and consult a dermatologist

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According to James Hou, founder of the Nanjing-based consultancy China Intellectual Property Consulting and Information, Novo Nordisks patent is rock solid: Its genuinely a remarkable technical achievement, he says

The purpose of this review is to (1) detail the renal and cardiovascular mechanisms of incretin-based therapies, (2) summarize the clinical evidence from completed and ongoing CVOTs, (3) discuss emerging agents such as the dual GLP-1/GIP agonist tirzepatide, and (4) highlight remaining knowledge gaps as the therapeutic paradigm shifts from glucose-centric to cardiorenal-centric care

Not sure if it was direct or indirect central modulation