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Firstly, the hypothalamus-pituitary adrenal (HPA) axis is under circadian control via arginine-vasopressin (AVP) projection from the SCN to the paraventricular nucleus (PVN), generating a rhythmic firing pattern in the downstream region 45

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The results were compared with a potent CB1 inverse agonist (AM251) administered orally at 10 mg/kg once daily or 5 mg/kg twice daily as a positive control

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However, consuming too few calories can lead to nutritional deficiencies, muscle loss, and fatigue, whilst excessive intake may limit therapeutic benefits