Epub 2011 Mar 31
A key aspect of FOXO4's function lies in its involvement in insulin and insulin-like growth factor (IGF) signaling pathways, which regulate metabolism, cell cycle progression, and apoptosis
Dolma S, Lessnick SL, Hahn WC, Stockwell BR
Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)
How it works: MOTS-C is a naturally occurring mitochondrial peptide discovered at USC in 2015
Since your body already knows how to use it, the concern is less about the molecule itself and more about the purity, dosage, and delivery method of the supplement