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In McCormick DB, Wright LD (eds.)

Notably, combined approaches (e.g., structural modification + formulation optimization) can further enhance efficacy: for instance, reducing diosgenins hemolytic toxicity through cholesterol nanocomplex formation achieves integration of structural interactions and nanodelivery

Eur J Biochem 1990

The medication is primarily eliminated through protein catabolism rather than traditional hepatic metabolism, meaning liver disease typically does not substantially affect elimination rates

Discontinue use if irritation, redness, or rash occurs