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Inflammatory cytokines notably interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-) play a critical role in plaque progression and instability, increasing the risk of plaque rupture and acute events such as myocardial infarction and stroke [34]

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ROCK has a significant inhibitory effect on cell survival and axon growth, and the upregulation of ROCK2 is considered a marker of activation of the RhoA/ROCK pathway in the brain

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