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While some gene-level differences were noted between fetal and adult tissue, fibroblast population identities and spatial localizations were maintained

15 Despite proven efficacy, there are recent safety concerns regarding sitagliptin use

Senolytic compounds under evaluation in phase 2 clinical trials include a combination of dasatinib (a tyrosine kinase inhibitor approved by FDA for the treatment of leukemia) and quercetin (a flavonoid with anti-inflammatory properties) (Cummings et al., 2024

SAMe is considered to be the universal methyl donor for all methylation reactions including donating a methyl group for DNA and RNA, proteins and neurotransmitters

5.3 Underutilization of diet-based microbiota modulation Despite substantial evidence linking diet to microbiota composition and function, dietary interventions remain underemphasized in hypothyroidism management

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