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Taken together, these results are clear proof of concept that impaired insulin signaling is a key driver of AD and that improving insulin signaling can improve cognition and key disease biomarkers of AD

It says the class numbers at least 100,000 people

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Nature 498, 99103

He gets a little high and behaves badly, but it gives me something to bounce off of. Stop stalling Dont get into a position where you say to yourself, I should have made better choices. Its never too late to start

Two investigators (HW and TG) independently assessed the quality of each included study using Cochrane risk of bias instrument [21]