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CINCA/NOMID manifests early in life with a non-pruritic rash, aseptic meningitis, deforming arthropathy, skeletal abnormalities, and distinctive facial features such as frontal bossing and saddle-nose deformity (70)

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The authors not only confirmed previous findings, such as the role of open-reading frame 3a (ORF3a) in extensive membrane remodeling and viral budding through interactions with VPS39 and VPS11, but also identified potential interactions between ORF3a and cell adhesion factors