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Lafferty RA, FP R, Irwin N

Neoplasia 32 , 100830 (2022)

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These substitutions protect against dipeptidyl peptidase-IV (DPP-IV) cleavage, the enzyme that destroys natural GHRH within minutes (Alba et al., J Med Chem 2006)

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Semaglutide at 14.9%, Tirzepatide at 20.9%, and Retatrutide at 24.2% demonstrate this stepwise improvement