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This hypothesis is supported by post-mortem evidence of reduced pyruvate dehydrogenase activity in the brains of individuals with ASD (Gu et al., 2013), which may impair the conversion of pyruvate to acetyl-CoA, leading to mitochondrial dysfunction and accumulation of lactate and alanine

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Adjustments may be necessary to avoid dangerous drops in blood sugar or gastrointestinal discomfort

The microbiota in cirrhosis and its role in hepatic decompensation

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