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Accumulating evidence highlights the importance of these LDSFs in CVDs, such as atherosclerosis, CHD, thrombosis, MI, HF, metabolic cardiomyopathy, arterial hypertension, and pulmonary hypertension

Key Takeaways "Safety" depends on context: Laboratory handling safety, compound purity, and clinical safety profiles are three different questions Purity is the #1 variable: A 98% pure peptide and a 70% pure peptide are not the same product contamination is the primary risk factor Third-party testing is the standard: Vendor-provided COAs are a starting point

PloS One (2011) 6(4):e19107

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In agreement with these latter results, the work of Majors et al (1997) showed that a relatively low concentration of homocysteine (50 to 300 mol/L) stimulates collagen production in rabbit aortic smooth muscle cells that may favor extracellular matrix component accumulation in intimal lesions

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