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Braidy, Rejuvenation Res

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Senolytics like Dasatinib (D) and Quercetin(Q) have shown potential in slowing the aging of human endometrial stromal cells and mouse uterine tissue [15]

Their major limitations include: (1) Their immunogenicity which can create an inflammatory response in the donor which can lead to degeneration of the transducted tissue, (2) they can produce non-specific toxins, (3) due to the semi-random integration to the genome, there is a theoretical risk of insertional mutagenesis, (4) they have limitations of transgenic capacity size

It is crucial to understand that this formulation is contraindicated in patients with a known hypersensitivity to methylcobalamin or any of its components

Injection site reactions (irritation, erythema, induration, pain, itching) in approximately 70% of subjects on drug and rarely on placebo more severe and/or prolonged after higher doses