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It also activates 7 nicotinic acetylcholine receptor, reducing the inflammatory cytokines produced via the vagus nerve, reversing IL-1-related microglial activation induced by depression, and thereby inhibiting peripheral and central inflammatory responses to improve depressive symptoms [191,192,193]

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36 The orobuccal absorptive surface area is approximately 200 cm 2 , supplied by a rich vascular network

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