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10 The present study adopted the same modeling perspective and population structure but introduced the following 3 predefined modifications to better reflect realistic long-term obesity management pathways: Retreatment module: A new module was incorporated to allow the assessment of clinical and economic outcomes associated with re-initiating semaglutide following treatment discontinuation

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The amino acid sequence is the same compound that Eli Lilly has published, but the research-grade material supplied here is not equivalent to Eli Lilly's investigational drug product, is not produced under the same regulatory framework, and is not a substitute for any clinical trial supply, compounded preparation, or future approved formulation