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[6] Scientists working with test models also comment that IGF-1 may have a GH independent growth stimulating effect, which with respect to cartilage cells is possibly optimized by the synergistic action with GH

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10.1016/j.pnpbp.2006.10.010 Prog

Dysregulation of this pathway can bias TRP metabolism toward neurotoxic and pro-inflammatory metabolites, thereby amplifying excitotoxicity, oxidative stress, and immune-driven disturbances in glutamatergic and monoaminergic neurotransmission

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Upon addition of GSH, a new emission peak at 520 nm emerges and the intensity is rising along with the increase of GSH concentration (Figure 4A)