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During this absorption window, blood flow to the injection site directly affects how much peptide reaches systemic circulation and how much remains concentrated locally

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After 72 weeks, participants on Zepbound lost an average of 20.2% of their body weight (averaging 50 pounds), compared to 13.7% (around 33 pounds) for those on the 2.4 mg dose of Wegovy (later studies of the 7.2 mg dose of Wegovy have showed 18.7% weight loss)