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Interestingly, VCN-01, an oncolytic virus expressing hyaluronidase, showed encouraging clinical activity in PDAC, achieving an ORR of 50% in a phase I trial [440], implying that the delivery method for HA-degrading enzyme could make a difference in therapeutic outcomes

Metabolic and redox signaling in the retina

LOXL2 cloning and mutagenesis The Loxl2 cDNA (fusion clone) was obtained from DNAsu in pDONR entry vector

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang J: Bioconductor: open software development for computational biology and bioinformatics

doi: 10.3109/15563650.2013.802797

BPC 157 enhanced the phosphorylation of Src, Cav-1 and eNOS which was abolished by pretreatment with Src inhibitor, confirming the upstream role of Src in this signal pathway