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The proper functioning of GPX4, a member of the GPX family responsible for converting cytotoxic lipid hydroperoxides (L-OOH) into nontoxic lipid alcohols (L-OH), thus preventing the formation of lethal lipid ROS, is dependent on the indispensable cofactor GSH ( de novo synthesis of GSH, which is promoted by glutamate cysteine ligase (GCL) and glutathione synthetase (GSS)

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The Effect of Dietary Supplementation with n-3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

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It was hypothesized that the lack of activity was due to the increased hydrophilicity provided by the sulfur-containing bridging unit when compared to the control analog used, lipobactin, in which the lipid is attached directly to the N -terminus