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These are rare at the doses used in supervised clinical care and when they occur, they're typically mild and transient

Phase II methylation of estrogen requires the COMT enzyme (catechol oxygen methyltransferase)

Longer cycles should include careful self-monitoring and ideally involve periodic blood work including copper levels

Lab work shows they can stimulate dermal papilla cells, protect follicle cells from programmed cell death, and support antioxidant defenses in the scalp, which may help counter some of the cellular damage that accumulates as AGA progresses

Liu H, Guo X, Chu Y, Lu S

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