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in mice that were administered a high-fat diet (HFD) and the antibiotic streptozotocin (STZ), the active compound genistein, belonging to the isoflavone family, demonstrated a reduction in insulin resistance and inflammation responses

Antioxidants 8(4):105

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The tradeoff is that higher daily doses can increase the likelihood of GI discomfort in some people

Patients with specific genetic profiles may experience better outcomes with dosage escalation, while others benefit from switching compounds or incorporating dual-action formulations

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