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For RCTs, this included assessment of: (1) risk of bias (via Cochrane RoB 2 tool), (2) inconsistency of results across studies, (3) indirectness of evidence, (4) imprecision due to sample size or confidence intervals, and (5) potential publication bias

Likewise, there are no problems related to polyphenol accumulation in the body, as they are hydrosoluble and are excreted by the renal and digestive system

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doi: 10.1080/21641846.2012.733602 543 GeraghtyKHannMKurtevS

The result is a feedback loop that no single intervention reliably interrupts which is precisely the terrain where peptide-based therapies become clinically relevant