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The estimated mean annualized bleeding rate (ABR) (primary endpoint) was significantly lower with fitusiran compared to on-demand treatment (3.1 versus 31, respectively

Upon presentation, additional laboratory studies are necessary to obtain other important clinical parameters, including arterial blood gas (to investigate acid/base status), coagulation profile, basic metabolic panel, hepatic function tests, and urine drug screen (to determine possible co-ingestions).54 A negative APAP reading should not be interpreted as APAP-related hepatic injury having not taken place, as levels may be undetectable while liver damage has already occurred

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only 18% of it reaches the bloodstream

The challenge isnt creating more GLP-1its understanding how to activate the cells that produce it and protect the hormone from rapid degradation

Scuderi, Debora