Intranasal administration bypasses first-pass hepatic metabolism and offers a controlled route for preclinical bioavailability investigations, making the formulation relevant to peptide mucosal delivery and pharmacokinetic research protocols
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doi: 10.1002/glia.20467 47 WakabayashiCKiyamaYKunugiHManabeTIwakuraY
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Physical Properties Critical physicochemical parameters are summarized in Table 1
Phosphoribosyl pyrophosphate synthetase 1 (PRPS1), the key enzyme of the de novo nucleotide synthesis pathway, is O -GlcNAcylated by O -GlcNAc transferase (OGT), which triggers PRPS1 hexamer formation and relieves nucleotide product-mediated feedback inhibition, thereby boosting PRPS1 activity