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The American Diabetes Association's Standards of Medical Care and the prescribing information for semaglutide both support comprehensive metabolic evaluation before and during treatment.[1,2] In practice, however, these evaluations are inconsistent, which is why patients who ask specific questions get better care

This finding is in line with recent findings of a gradual decrease of adiponectin levels from metabolically healthy lean to metabolically healthy obese to metabolically unhealthy obese persons 49

American regulators should do the same