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Functional studies in rat models have demonstrated that injection of GLP-1 has a dose-dependent effect on reducing feeding behaviors [54, 55], providing evidence of its function as a satiety mediator

It also cites an unnamed 2023 observational study reporting larger pain-score improvements at higher weight loss, but since that study is never identified, its specific figures cannot be verified

However, results vary significantly based on individual factors like baseline carnitine status, diet composition, and exercise intensity

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In other words, comprehensive management focused on preventing cardiovascular disease is important, regardless of the duration of diabetes