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Metabolic liver health (MASLD) A phase 2a randomised trial in Nature Medicine examined retatrutide in adults with metabolic-dysfunction-associated steatotic liver disease

Targeting more than one receptor seems to boost the medications weight-loss effects

Typical trial exclusion criteria for retatrutide studies, consistent with those applied to similar investigational and licensed medicines in this class, have included: pregnancy or breastfeeding (with active contraception requirements during participation)

The most common are digestive issues (stomach-related), particularly when first starting treatment or after increasing the dose

212,213,390 Within this axis, GLP-1 functions by acting on both the gut and the brain