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For most of these types of lipidation, alkyne- or azide-modified lipid precursors have been generated that enable metabolic labeling of lipidated proteins and, following CuAAC tagging and then profiling by in-gel fluorescence or affinity enrichment for identification by MS-based proteomics (Figure 66)

In contrast, approximately 92% and 87% of D-CuP remained unchanged after 0.5 and 4 h of protease K exposure, highlighting its superior protease stability

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Geriatric population increasingly require therapies that offer glycemic control, weight reduction benefits, and broader cardiometabolic support