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Hormonal Changes Weight loss can lead to alterations in hormones like testosterone and growth hormone , which play a role in muscle maintenance

All 5 CVOTs reported reduction in hospitalization for HF, including DAPA-HF, which evaluated HF hospitalization and cardiovascular death as a composite primary outcome in patients with baseline chronic HF with reduced ejection fraction

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10.2337/dc19-1065 [DOI] [PMC free article] [PubMed] [Google Scholar] Bou Ghanem G

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[62]) carried out a phase 1 study with 47 healthy participants without diabetes participants receiving single ascending dose of retatrutide (0.1, 0.3, 1, 3, 4.5, or 6 mg) versus placebo