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A recent randomized trial of rifaximin solid soluble dispersion aimed at preventing a first episode of OHE in patients with portal hypertension did not fulfill the primary endpoint [115]

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Acute pancreatitis has been reported with GLP-1 receptor agonists, though a definitive causal relationship remains debated in the literature

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Whilst gastrointestinal symptoms dominate the adverse effect profile, some patients report experiencing changes to their skin during treatment