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Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin

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It has been shown to counteract NSAID-induced ulcers, esophagitis, and inflammatory bowel conditions like colitis by promoting epithelial integrity, increasing mucosal blood flow, and regulating the gut-brain axis

, Axelrod D., Singh B., and Kleinberg D

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CMS121 was shown to improve memory, and cognitive function in APPswe/PS1 E9 double transgenic mice ( LOX inhibitors 5-Lipoxygenase (5LO) is widely expressed in central nervous system neurons, and its levels increase in an age-dependent manner in the hippocampus and cortex, two brain regions prone to neurodegenerative damage