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In addition, to investigate the expression pattern and levels of ENaC in the patients with diabetes taking SGLT2is, DPP4is, or the combination of the two agents, the paraffin samples were collected from the renal biopsy database of the division of nephrology, Kurume university hospital

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It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists , which work by mimicking the action of a naturally occurring hormone in the body

This allows us to capture a sufficient number of spontaneous transport events to fully characterize their transport mechanisms, kinetics, and thermodynamics via multi-microsecond equilibrium MD simulations at physiological temperatures

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