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However, semaglutide oral tablets are not approved for the reduction of CV events.As with other agents in this class, semaglutide has a boxed warning regarding rodent thyroid C-cell tumor findings and the uncertain relevance to humans.First-line T2DM therapy depends on comorbidities, patient-centered treatment factors, and management needs and generally includes metformin and comprehensive lifestyle modification

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The latter is characterized by glomerular hyperfiltration, glomerular/tubular hypertrophy, and thickening of the glomerular basement membrane and mesangial matrix expansion/proliferation, resulting in increased glomerular permeability with consecutive albuminuria and progressive CKD [195]