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Additionally, one study showed that nearly 50% of HE recurrence was related to either no adherence or inappropriate dosing [59]

The pivotal trial, STEP 1, randomized 1,961 adults with a BMI of 30 or higher (or 27 with a weight-related comorbidity) to weekly semaglutide 2.4 mg or placebo, both alongside lifestyle counseling

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Tepmongkol et al., 2008) was reported in a phase II clinical trial that on the other hand concluded a not complete response of patients (Kebebew et al., 2009)

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The company has acknowledged short-term impacts from the tariffs and has previously signaled a willingness to expand U.S