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Despite limited clinical evidence exists regarding the comprehensive cardiovascular impacts of concurrent treatment with these agents in patients with T2D 18,19,20 , and preclinical studies suggest potential synergistic effects for MASLD 17 , there is a critical need for robust clinical research to evaluate the effect of combined SGLT2is and GLP-1RAs in patients with MASLD

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Treatment of actinic keratosis (AK) and Bowens disease (BD), both of which can progress to invasive SCC will also be discussed in this article

81 Obeticholic acid (OCA), the natural agonist of the farnesoid X receptor, could decreases insulin resistance and hepatic steatosis in preclinical research

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