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29,37 The biological basis of these differences remains poorly understood, and current evidence is largely derived from adult populations

The finding that a long-acting GIP receptor agonist (LAGIPRA) increases insulin sensitivity by promoting glucose capture in WAT confirms this

Here is the honest state of the data: Obesity (Phase 2, randomized controlled trial): the landmark New England Journal of Medicine Phase 2 trial in obesity established both the once-weekly dosing and the escalation approach, and reported the largest average weight reductions seen for a once-weekly agent with the caveat that the reduction had not fully plateaued at 48 weeks

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