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Individual marketplace plans have higher coverage rates (45%)

The cell suspension was lysed on ice by sonication and the lysate was centrifuged at 17,000 g for 30 min at 4 C to remove the insoluble cellular debris

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Diets that contribute to excessive SUA levels can induce the formation and deposition of MSU crystals, and other factor changes, such as diet-induced fluid acidification and salt deposition, also promote the growth of urate crystallization [24]

Nausea occurs in approximately 15-20% of patients and represents the most common side effect, typically emerging during dose escalation and often diminishing over several weeks as tolerance develops