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Beeswax is likely used for its thickening properties, helping to form a protective layer

First, tumours can affect the liver, which stores large amounts of B12

However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue (L585) weakens receptor binding, reducing its half-life from 20 days to 3.5 days in humans

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For example, people with certain anemia or on specific chemotherapy might need both