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Additional information Peer review information Nature Communications thanks Stevan Hubbard, Kenneth Siddle and the other, anonymous, reviewer for their contribution to the peer review of this work

the mechanical impingement features are not correctible by altering the mechanical mal-alignment

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A researcher who misreads a 250 mcg dose as 250 mg is off by a factor of 1,000

Others may find that monthly injections work best for them

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