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Acknowledgements This work was supported by grants from the Swedish Cancer Fund (Cancerfonden), the Swedish Research Council (VR), Radiumhemmets Forskningsfonder and Karolinska Institutet

proposed a nanocluster, which integrated catalase (CAT) with MnO 2 to realize CAT-triggered oxygen release and Mn 4+ -assisted GSH exhaustion, accompanied by abundant 1 O 2 accumulation, achieving a remarkable anticancer performance characterized by GSH depletion-improved PDT (Zhu et al., 2020)

Adding semaglutide to retatrutide would duplicate GLP-1 receptor activation, which could increase side effects without proportionally increasing efficacy

Talk to your physician before adjusting any supplement protocol

Manage stress: Practice stress-reducing techniques, such as meditation, yoga, or deep breathing exercises, to prevent stress-induced skin issues like acne or eczema