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Biomarkers of ROS-induced chemical modifications This class involves biomarkers resulting from the direct attack of ROS/RNS in biomolecules such as modifications of proteins

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Specifically, ROS will cause lipid peroxidation of the cell membrane of thyroid cells, destroy the integrity and fluidity of the cell membrane, affect the uptake of iodine and other nutrients, and interfere with the synthesis of thyroid hormone (Ates et al., 2015)