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6.2 Central integration and value adjustment: coordinated regulation by homeostatic and reward pathways Compared with peripheral mechanisms, central integrative pathways provide a more comprehensive explanation for the systemic effects of GLP-1RAs on eating experience and behaviour

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Emily Gallagher, a endocrinologist and physician scientist at Mount Sinai

Managing Side Effects GLP-1 drugs can result in substantial gastrointestinal side effects, including diarrhea, nausea, and vomiting

Risk: High costs, limited evidence of sustained outcomes without structured programs

Id also have to do a careful analysis and look for confounders - and there are many potentials